A trial to reduce hepatitis C seroincidence in drug users

TitleA trial to reduce hepatitis C seroincidence in drug users
Publication TypeJournal Article
Year of Publication2009
AuthorsStein, MD, Herman, DS, Anderson, BJ
JournalJournal of Addictive Diseases
PublisherTaylor & Francis
Place PublishedUnited Kingdom
Publication Languageeng
ISBN Number1055-08871545-0848
Accession Number2010-12074-010. First Author & Affiliation: Stein, Michael D.
KeywordsDrug abuse, Harm Reduction, Hepatitis, hepatitis C virus seroincidence, injection drug usage, Intervention, Intravenous Drug Usage, Motivational intervention, motivational interviewing, prevention, Treatment Effectiveness Evaluation

To test whether a four-session motivational intervention would reduce hepatitis C virus (HCV) seroincidence among injection and non-injection drug users compared to an assessment-only condition, we performed a randomized 24-month clinical trial. At baseline, 277 participants reported using heroin or cocaine at least three times weekly were HCV antibody negative, 65% were male and 46% were Caucasian and 39% reported having injected drugs. Of the 15 (5.4%) individuals who seroconverted, all reported injecting drugs either at baseline or during follow-up. Seroconversion rates did not differ significantly by treatment assignment (p = .79). The annual HCV incident rate was 8.20 (95% confidence interval [CI] = 4.76-14.13) for injectors and 0.74 (95% CI = 0.19-2.98) for non-injectors per 100 person-years. Significantly fewer participants in the intervention group initiated injection drug use behaviors (p = .009). This intervention was no more effective at reducing HCV seroconversion than assessment alone but did decrease injection initiation. (PsycINFO Database Record (c) 2010 APA, all rights reserved) (journal abstract)

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